One of the best genealogy conferences in the country is run by the all-volunteer Southern California Genealogical Society every June. It's in Burbank (though not in the Beautiful Downtown) and is a blast. Three days (four with the DNA symposium) of programs and communion with fellow pursuers of the past, an exhibit hall with every major record provider and a venue run by downright nice people. What more can one want?
The location is great–the Burbank Marriott and Convention Center, right across the street from the Burbank Airport. Turn right and go to the SCGS library of 40,000+ volumes. Turn left and dead end at Warner Brothers Studio. There's even a tour of Hollywood Forever Cemetery!